diff --git a/drivers/bluetooth/hci_qca.c b/drivers/bluetooth/hci_qca.c
index 74f5fede0274..d98ed0442201 100644
--- a/drivers/bluetooth/hci_qca.c
+++ b/drivers/bluetooth/hci_qca.c
@@ -168,6 +168,7 @@ struct qca_serdev {
 
 static int qca_power_setup(struct hci_uart *hu, bool on);
 static void qca_power_shutdown(struct hci_uart *hu);
+static int qca_power_off(struct hci_dev *hdev);
 
 static void __serial_clock_on(struct tty_struct *tty)
 {
@@ -1099,8 +1100,26 @@ static int qca_set_speed(struct hci_uart *hu, enum qca_speed_type speed_type)
 static int qca_wcn3990_init(struct hci_uart *hu)
 {
 	struct hci_dev *hdev = hu->hdev;
+	struct qca_serdev *qcadev;
 	int ret;
 
+	/* Check for vregs status, may be hci down has turned
+	 * off the voltage regulator.
+	 */
+	qcadev = serdev_device_get_drvdata(hu->serdev);
+	if (!qcadev->bt_power->vregs_on) {
+		serdev_device_close(hu->serdev);
+		ret = qca_power_setup(hu, true);
+		if (ret)
+			return ret;
+
+		ret = serdev_device_open(hu->serdev);
+		if (ret) {
+			bt_dev_err(hu->hdev, "failed to open port");
+			return ret;
+		}
+	}
+
 	/* Forcefully enable wcn3990 to enter in to boot mode. */
 	host_set_baudrate(hu, 2400);
 	ret = qca_send_power_pulse(hdev, QCA_WCN3990_POWEROFF_PULSE);
@@ -1152,6 +1171,12 @@ static int qca_setup(struct hci_uart *hu)
 
 	if (qcadev->btsoc_type == QCA_WCN3990) {
 		bt_dev_info(hdev, "setting up wcn3990");
+
+		/* Enable NON_PERSISTENT_SETUP QUIRK to ensure to execute
+		 * setup for every hci up.
+		 */
+		set_bit(HCI_QUIRK_NON_PERSISTENT_SETUP, &hdev->quirks);
+		hu->hdev->shutdown = qca_power_off;
 		ret = qca_wcn3990_init(hu);
 		if (ret)
 			return ret;
@@ -1242,6 +1267,14 @@ static void qca_power_shutdown(struct hci_uart *hu)
 	qca_power_setup(hu, false);
 }
 
+static int qca_power_off(struct hci_dev *hdev)
+{
+	struct hci_uart *hu = hci_get_drvdata(hdev);
+
+	qca_power_shutdown(hu);
+	return 0;
+}
+
 static int qca_enable_regulator(struct qca_vreg vregs,
 				struct regulator *regulator)
 {