diff --git a/python/.gitignore b/python/.gitignore
index 4ed144ceac..272ed223a8 100644
--- a/python/.gitignore
+++ b/python/.gitignore
@@ -13,3 +13,4 @@ qemu.egg-info/
 
 # virtual environments (pipenv et al)
 .venv/
+.tox/
diff --git a/python/Makefile b/python/Makefile
index a9da168955..b5621b0d54 100644
--- a/python/Makefile
+++ b/python/Makefile
@@ -16,6 +16,8 @@ help:
 	@echo ""
 	@echo "make check:      run linters using the current environment."
 	@echo ""
+	@echo "make check-tox:  run linters using multiple python versions."
+	@echo ""
 	@echo "make clean:      remove package build output."
 	@echo ""
 	@echo "make distclean:  remove venv files, qemu package forwarder,"
@@ -36,8 +38,11 @@ develop:
 check:
 	@avocado --config avocado.cfg run tests/
 
+check-tox:
+	@tox
+
 clean:
 	python3 setup.py clean --all
 
 distclean: clean
-	rm -rf qemu.egg-info/ .venv/ dist/
+	rm -rf qemu.egg-info/ .venv/ .tox/ dist/
diff --git a/python/setup.cfg b/python/setup.cfg
index fd32519490..0fcdec6f32 100644
--- a/python/setup.cfg
+++ b/python/setup.cfg
@@ -14,6 +14,11 @@ classifiers =
     Natural Language :: English
     Operating System :: OS Independent
     Programming Language :: Python :: 3 :: Only
+    Programming Language :: Python :: 3.6
+    Programming Language :: Python :: 3.7
+    Programming Language :: Python :: 3.8
+    Programming Language :: Python :: 3.9
+    Programming Language :: Python :: 3.10
 
 [options]
 python_requires = >= 3.6
@@ -30,12 +35,13 @@ devel =
     isort >= 5.1.2
     mypy >= 0.770
     pylint >= 2.8.0
-
+    tox >= 3.18.0
 
 [flake8]
 extend-ignore = E722  # Prefer pylint's bare-except checks to flake8's
 exclude = __pycache__,
           .venv,
+          .tox,
 
 [mypy]
 strict = True
@@ -79,3 +85,18 @@ include_trailing_comma=True
 line_length=72
 lines_after_imports=2
 multi_line_output=3
+
+# tox (https://tox.readthedocs.io/) is a tool for running tests in
+# multiple virtualenvs. This configuration file will run the test suite
+# on all supported python versions. To use it, "pip install tox" and
+# then run "tox" from this directory. You will need all of these versions
+# of python available on your system to run this test.
+
+[tox:tox]
+envlist = py36, py37, py38, py39, py310
+
+[testenv]
+allowlist_externals = make
+deps = .[devel]
+commands =
+    make check