diff --git a/hw/vfio/common.c b/hw/vfio/common.c
index 6065834717..cfcb71974a 100644
--- a/hw/vfio/common.c
+++ b/hw/vfio/common.c
@@ -40,6 +40,7 @@
 #include "trace.h"
 #include "qapi/error.h"
 #include "migration/migration.h"
+#include "sysemu/tpm.h"
 
 VFIOGroupList vfio_group_list =
     QLIST_HEAD_INITIALIZER(vfio_group_list);
@@ -861,6 +862,22 @@ static void vfio_unregister_ram_discard_listener(VFIOContainer *container,
     g_free(vrdl);
 }
 
+static bool vfio_known_safe_misalignment(MemoryRegionSection *section)
+{
+    MemoryRegion *mr = section->mr;
+
+    if (!TPM_IS_CRB(mr->owner)) {
+        return false;
+    }
+
+    /* this is a known safe misaligned region, just trace for debug purpose */
+    trace_vfio_known_safe_misalignment(memory_region_name(mr),
+                                       section->offset_within_address_space,
+                                       section->offset_within_region,
+                                       qemu_real_host_page_size());
+    return true;
+}
+
 static void vfio_listener_region_add(MemoryListener *listener,
                                      MemoryRegionSection *section)
 {
@@ -884,7 +901,15 @@ static void vfio_listener_region_add(MemoryListener *listener,
     if (unlikely((section->offset_within_address_space &
                   ~qemu_real_host_page_mask()) !=
                  (section->offset_within_region & ~qemu_real_host_page_mask()))) {
-        error_report("%s received unaligned region", __func__);
+        if (!vfio_known_safe_misalignment(section)) {
+            error_report("%s received unaligned region %s iova=0x%"PRIx64
+                         " offset_within_region=0x%"PRIx64
+                         " qemu_real_host_page_size=0x%"PRIxPTR,
+                         __func__, memory_region_name(section->mr),
+                         section->offset_within_address_space,
+                         section->offset_within_region,
+                         qemu_real_host_page_size());
+        }
         return;
     }
 
diff --git a/hw/vfio/trace-events b/hw/vfio/trace-events
index 0ef1b5f4a6..582882db91 100644
--- a/hw/vfio/trace-events
+++ b/hw/vfio/trace-events
@@ -100,6 +100,7 @@ vfio_listener_region_add_skip(uint64_t start, uint64_t end) "SKIPPING region_add
 vfio_spapr_group_attach(int groupfd, int tablefd) "Attached groupfd %d to liobn fd %d"
 vfio_listener_region_add_iommu(uint64_t start, uint64_t end) "region_add [iommu] 0x%"PRIx64" - 0x%"PRIx64
 vfio_listener_region_add_ram(uint64_t iova_start, uint64_t iova_end, void *vaddr) "region_add [ram] 0x%"PRIx64" - 0x%"PRIx64" [%p]"
+vfio_known_safe_misalignment(const char *name, uint64_t iova, uint64_t offset_within_region, uintptr_t page_size) "Region \"%s\" iova=0x%"PRIx64" offset_within_region=0x%"PRIx64" qemu_real_host_page_size=0x%"PRIxPTR ": cannot be mapped for DMA"
 vfio_listener_region_add_no_dma_map(const char *name, uint64_t iova, uint64_t size, uint64_t page_size) "Region \"%s\" 0x%"PRIx64" size=0x%"PRIx64" is not aligned to 0x%"PRIx64" and cannot be mapped for DMA"
 vfio_listener_region_del_skip(uint64_t start, uint64_t end) "SKIPPING region_del 0x%"PRIx64" - 0x%"PRIx64
 vfio_listener_region_del(uint64_t start, uint64_t end) "region_del 0x%"PRIx64" - 0x%"PRIx64