diff --git a/exec.c b/exec.c
index d6712fba7e..c5ab59ec44 100644
--- a/exec.c
+++ b/exec.c
@@ -77,6 +77,10 @@
 
 #include "monitor/monitor.h"
 
+#ifdef CONFIG_LIBDAXCTL
+#include <daxctl/libdaxctl.h>
+#endif
+
 //#define DEBUG_SUBPAGE
 
 #if !defined(CONFIG_USER_ONLY)
@@ -1745,6 +1749,46 @@ static int64_t get_file_size(int fd)
     return size;
 }
 
+static int64_t get_file_align(int fd)
+{
+    int64_t align = -1;
+#if defined(__linux__) && defined(CONFIG_LIBDAXCTL)
+    struct stat st;
+
+    if (fstat(fd, &st) < 0) {
+        return -errno;
+    }
+
+    /* Special handling for devdax character devices */
+    if (S_ISCHR(st.st_mode)) {
+        g_autofree char *path = NULL;
+        g_autofree char *rpath = NULL;
+        struct daxctl_ctx *ctx;
+        struct daxctl_region *region;
+        int rc = 0;
+
+        path = g_strdup_printf("/sys/dev/char/%d:%d",
+                    major(st.st_rdev), minor(st.st_rdev));
+        rpath = realpath(path, NULL);
+
+        rc = daxctl_new(&ctx);
+        if (rc) {
+            return -1;
+        }
+
+        daxctl_region_foreach(ctx, region) {
+            if (strstr(rpath, daxctl_region_get_path(region))) {
+                align = daxctl_region_get_align(region);
+                break;
+            }
+        }
+        daxctl_unref(ctx);
+    }
+#endif /* defined(__linux__) && defined(CONFIG_LIBDAXCTL) */
+
+    return align;
+}
+
 static int file_ram_open(const char *path,
                          const char *region_name,
                          bool *created,
@@ -2296,7 +2340,7 @@ RAMBlock *qemu_ram_alloc_from_fd(ram_addr_t size, MemoryRegion *mr,
 {
     RAMBlock *new_block;
     Error *local_err = NULL;
-    int64_t file_size;
+    int64_t file_size, file_align;
 
     /* Just support these ram flags by now. */
     assert((ram_flags & ~(RAM_SHARED | RAM_PMEM)) == 0);
@@ -2332,6 +2376,14 @@ RAMBlock *qemu_ram_alloc_from_fd(ram_addr_t size, MemoryRegion *mr,
         return NULL;
     }
 
+    file_align = get_file_align(fd);
+    if (file_align > 0 && mr && file_align > mr->align) {
+        error_setg(errp, "backing store align 0x%" PRIx64
+                   " is larger than 'align' option 0x" PRIx64,
+                   file_align, mr->align);
+        return NULL;
+    }
+
     new_block = g_malloc0(sizeof(*new_block));
     new_block->mr = mr;
     new_block->used_length = size;