diff --git a/block/qcow2.c b/block/qcow2.c
index e8934de185..2e346d8c42 100644
--- a/block/qcow2.c
+++ b/block/qcow2.c
@@ -1537,8 +1537,21 @@ static int qcow2_write_compressed(BlockDriverState *bs, int64_t sector_num,
         return 0;
     }
 
-    if (nb_sectors != s->cluster_sectors)
-        return -EINVAL;
+    if (nb_sectors != s->cluster_sectors) {
+        ret = -EINVAL;
+
+        /* Zero-pad last write if image size is not cluster aligned */
+        if (sector_num + nb_sectors == bs->total_sectors &&
+            nb_sectors < s->cluster_sectors) {
+            uint8_t *pad_buf = qemu_blockalign(bs, s->cluster_size);
+            memset(pad_buf, 0, s->cluster_size);
+            memcpy(pad_buf, buf, nb_sectors * BDRV_SECTOR_SIZE);
+            ret = qcow2_write_compressed(bs, sector_num,
+                                         pad_buf, s->cluster_sectors);
+            qemu_vfree(pad_buf);
+        }
+        return ret;
+    }
 
     out_buf = g_malloc(s->cluster_size + (s->cluster_size / 1000) + 128);